Combinatorial liposomal peptide vaccine induces IgA and confers protection against influenza virus and bacterial super-infection.

ABSTRACT:

Objectives

The upper respiratory tract is the major entry site for Streptococcus pyogenes and influenza virus. Vaccine strategies that activate mucosal immunity could significantly reduce morbidity and mortality because of these pathogens. The severity of influenza is significantly greater if a streptococcal infection occurs during the viraemic period and generally viral infections complicated by a subsequent bacterial infection are known as super-infections. We describe an innovative vaccine strategy against influenza virus:S. pyogenes super-infection. Moreover, we provide the first description of a liposomal multi-pathogen-based platform that enables the incorporation of both viral and bacterial antigens into a vaccine and constitutes a transformative develop

SUBMITTER: Zaman M 

PROVIDER: S-EPMC8432089 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature