Transcranial magnetic stimulation as a tool to understand genetic conditions associated with epilepsy.

ABSTRACT: Advances in genetics may enable a deeper understanding of disease mechanisms and promote a shift to more personalised medicine in the epilepsies. At present, understanding of consequences of genetic variants mainly relies on preclinical functional work; tools for acquiring similar data from the living human brain are needed. Transcranial magnetic stimulation (TMS), in particular paired-pulse TMS protocols which depend on the function of cortical GABAergic interneuron networks, has the potential to become such a tool. For this report, we identified and reviewed 23 publications on TMS studies of cortical excitability and inhibition in 15 different genes or conditions relevant to epilepsy. Reduced short-interval intracortical inhibition (SICI) and reduced cortical silent period (CSP) duration

SUBMITTER: Silvennoinen K 

PROVIDER: S-EPMC8432162 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature