Extracellular GABA waves regulate coincidence detection in excitatory circuits.

ABSTRACT:

Key points

Rapid changes in neuronal network activity trigger widespread waves of extracellular GABA in hippocampal neuropil. Elevations of extracellular GABA narrow the coincidence detection window for excitatory inputs to CA1 pyramidal cells. GABA transporters control the effect of extracellular GABA on coincidence detection. Small changes in the kinetics of dendritic excitatory currents amplify when reaching the soma.

Abstract

Coincidence detection of excitatory inputs by principal neurons underpins the rules of signal integration and Hebbian plasticity in the brain. In the hippocampal circuitry, detection fidelity is thought to depend on the GABAergic synaptic input through a feedforward inhibitory circuit also involving the hyperpolarisation-activated I_h curr

SUBMITTER: Sylantyev S 

PROVIDER: S-EPMC8432164 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature