Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential.

ABSTRACT: The search to improve therapies to prevent or treat cardiovascular diseases (CVDs) rages on, as CVDs remain a leading cause of death worldwide. Here, the main cause of CVDs, atherosclerosis, and its prevention, take center stage. Chemokines and their receptors have long been known to play an important role in the pathophysiological development of atherosclerosis. Their role extends from the initiation to the progression, and even the potential regression of atherosclerotic lesions. These important regulators in atherosclerosis are therefore an obvious target in the development of therapeutic strategies. A plethora of preclinical studies have assessed various possibilities for targeting chemokine signaling via various approaches, including competitive ligands and microRNAs, which have shown

SUBMITTER: Marquez AB 

PROVIDER: S-EPMC8432216 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature