The Role of Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Leukemia.

ABSTRACT: Allogeneic hematopoietic stem cell transplantation (HSCT) offers potentially curative treatment for many children with high-risk or relapsed acute leukemia (AL), thanks to the combination of intense preparative radio/chemotherapy and the graft-versus-leukemia (GvL) effect. Over the years, progress in high-resolution donor typing, choice of conditioning regimen, graft-versus-host disease (GvHD) prophylaxis and supportive care measures have continuously improved overall transplant outcome, and recent successes using alternative donors have extended the potential application of allotransplantation to most patients. In addition, the importance of minimal residual disease (MRD) before and after transplantation is being increasingly clarified and MRD-directed interventions may be employed to fur

SUBMITTER: Algeri M 

PROVIDER: S-EPMC8432223 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature