Clinical Advancement and Challenges of ex vivo Expansion of Human Cord Blood Cells.

ABSTRACT: Apart from peripheral blood stem cell (PBSC), umbilical cord blood (UCB) is now a recognized source of stem cells for transplantation. UCB is an especially important source of stem cells for minority populations, which would otherwise be unable to find appropriately matched adult donors. UCB has fewer mature T lymphocytes compared with peripheral blood, thus making a UCB transplantation (UCBT) with a greater degree of HLA mismatch possible. The limited cell dose per UCB sample is however associated with delayed engraftment and a higher risk of graft failure, especially in adult recipients. This lower cell dose can be optimized by performing double unit UCBT, ex vivo UCB expansion prior to transplant and enhancement of the capabilities of the stem cells to home to the bone marrow. UC

SUBMITTER: Emiloju OE 

PROVIDER: S-EPMC8432338 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature