Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation.

ABSTRACT:

Background

Monocytes are an essential cellular component of the innate immune system that support the host's effectiveness to combat a range of infectious pathogens. Hemopoietic cell transplantation (HCT) results in transient monocyte depletion, but the factors that regulate recovery of monocyte populations are not fully understood. In this study, we investigated whether the composition of the gastrointestinal microbiota is associated with the recovery of monocyte homeostasis after HCT.

Methods

We performed a single-center, prospective, pilot study of 18 recipients of either autologous or allogeneic HCT. Serial blood and stool samples were collected from each patient during their HCT hospitalization. Analysis of the gut microbiota was done using 16S rRNA gene sequencing, and

SUBMITTER: Morjaria S 

PROVIDER: S-EPMC8432405 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature