Dipeptidase PEPDA Is Required for the Conidiation Pattern Shift in Metarhizium acridum.

ABSTRACT: Filamentous fungi conduct two types of conidiation, typical conidiation from mycelia and microcycle conidiation (MC). Fungal conidiation can shift between the two patterns, which involves a large number of genes in the regulation of this process. In this study, we investigated the role of a dipeptidase gene pepdA in conidiation pattern shift in Metarhizium acridum, which is upregulated in MC pattern compared to typical conidiation. Results showed that disruption of the pepdA resulted in a shift of conidiation pattern from MC to typical conidiation. Metabolomic analyses of amino acids showed that the levels of 19 amino acids significantly changed in ΔpepdA mutant. The defect of MC in ΔpepdA can be rescued when nonpolar amino acids, α-alanine, β-alanine, or prolin

SUBMITTER: Li J 

PROVIDER: S-EPMC8432524 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature