Genetic association of anthropometric traits with type 2 diabetes in ethnically endogamous Sindhi families.

ABSTRACT:

Background

Ethnically endogamous populations can shed light on the genetics of type 2 diabetes. Such studies are lacking in India. We conducted this study to determine the genetic and environmental contributions of anthropometric traits to type 2 diabetes risk in the Sindhi families in central India.

Methods

We conducted a family study in Indian Sindhi families with at least one case of type 2 diabetes. Variance components methods were used to quantify the genetic association of 18 anthropometric traits with eight type 2 diabetes related traits. Univariate and bivariate polygenic models were used to determine the heritability, genetic and environmental correlation of anthropometric traits with type 2 diabetes related traits.

Results

We included 1,152 individuals from

SUBMITTER: Mamtani M 

PROVIDER: S-EPMC8432747 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature