Vitamin D regulation of HAS2, hyaluronan synthesis and metabolism in triple negative breast cancer cells.

ABSTRACT: The vitamin D receptor (VDR) and its ligand 1,25(OH)₂D₃ (1,25D) exert anti-tumor effects, but considerable heterogeneity has been reported in different model systems. In general, cell lines derived from aggressive tumor subtypes such as Triple Negative Breast Cancer (TNBC) express low levels of VDR and are less sensitive to 1,25D than those derived from more differentiated tumor types. We have previously reported that 1,25D inhibits hyaluronic acid synthase 2 (HAS2) expression and hyaluronic acid (HA) synthesis in murine TNBC cells. Here we confirmed the inhibitory effect of 1,25D on HA synthesis in human Hs578T cells representative of the mesenchymal/stem-like (MSL) subtype of TNBC. Because HA synthesis requires the production of hexoses for incorporation into HA, we

SUBMITTER: Narvaez CJ 

PROVIDER: S-EPMC8432753 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature