Serum chemerin levels: A potential biomarker of joint inflammation in women with rheumatoid arthritis.

ABSTRACT:

Background

Chemerin has a potential role in perpetuating inflammation in autoimmune diseases. Nevertheless, to date, there is no conclusive information on whether high chemerin levels increase the severity of rheumatoid arthritis (RA). Therefore, this study evaluated whether serum chemerin is a biomarker of disease activity in RA patients.

Methods

Study design: cross-sectional. The assessment included clinical and laboratory characteristics, body mass index (BMI) and fat mass. The severity of the disease activity was identified according to the DAS28-CRP index as follows: A) RA with a DAS28-CRP≤2.9 (remission/mild activity) and B) RA with a DAS28-CRP>2.9 (moderate/severe activity). Serum chemerin concentrations were measured by ELISA, and ≥103 ng/mL was considered a high lev

SUBMITTER: Gonzalez-Ponce F 

PROVIDER: S-EPMC8432803 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature