Conjunctive spatial and self-motion codes are topographically organized in the GABAergic cells of the lateral septum.

ABSTRACT: The hippocampal spatial code's relevance for downstream neuronal populations-particularly its major subcortical output the lateral septum (LS)-is still poorly understood. Here, using calcium imaging combined with unbiased analytical methods, we functionally characterized and compared the spatial tuning of LS GABAergic cells to those of dorsal CA3 and CA1 cells. We identified a significant number of LS cells that are modulated by place, speed, acceleration, and direction, as well as conjunctions of these properties, directly comparable to hippocampal CA1 and CA3 spatially modulated cells. Interestingly, Bayesian decoding of position based on LS spatial cells reflected the animal's location as accurately as decoding using the activity of hippocampal pyramidal cells. A portion of LS cells sho

SUBMITTER: van der Veldt S 

PROVIDER: S-EPMC8432898 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature