Genetic Diversity of Multidrug-Resistant Pseudomonas aeruginosa Isolates Carrying bla _VIM-2 and bla _KPC-2 Genes That Spread on Different Genetic Environment in Colombia.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen with an increase in the frequency of infections caused by multidrug resistant (MDR) and extensively drug resistant (XDR) strains, limiting the available therapeutic options. The most troublesome resistance is the acquisition and production of carbapenemases such as Verona integron-encoded metallo-β-lactamases (VIM), the most frequent and widespread, and the Klebsiella pneumoniae carbapenemases (KPC), which has continuously spread in the last decade. Its dissemination is linked to their location on mobile genetic elements (MGEs). In Colombia, VIM and KPC have been increasing in its frequency showing major successful dissemination. In this article, we molecularly characterized and analyzed the genetic context of

SUBMITTER: Rada AM 

PROVIDER: S-EPMC8432936 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature