Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a major risk factor for the acquisition of latent tuberculosis (TB) infection (LTBI) and development of active tuberculosis (ATB), although the immunological basis for this susceptibility remains poorly characterised. Innate lymphoid cells (ILCs) immune responses to TB infection in T2DM comorbidity is anticipated to be reduced. We compared ILC responses (frequency and cytokine production) among adult patients with LTBI and T2DM to patients (13) with LTBI only (14), T2DM only (10) and healthy controls (11).

Methods

Using flow cytometry, ILC phenotypes were categorised based on (Lin^-CD127⁺CD161⁺) markers into three types: ILC1 (Lin^-CD127⁺CD161⁺CRTH2^-CD117<

SUBMITTER: Ssekamatte P 

PROVIDER: S-EPMC8432960 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature