A practical guide to promote informatics-driven efficient biotopographic material development.

ABSTRACT: Micro/nano topographic structures have shown great utility in many biomedical areas including cell therapies, tissue engineering, and implantable devices. Computer-assisted informatics methods hold great promise for the design of topographic structures with targeted properties for a specific medical application. To benefit from these methods, researchers and engineers require a highly reusable "one structural parameter - one set of cell responses" database. However, existing confounding factors in topographic cell culture devices seriously impede the acquisition of this kind of data. Through carefully dissecting the confounding factors and their possible reasons for emergence, we developed corresponding guideline requirements for topographic cell culture device development to remove or con

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8433058 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature