Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC8433065 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Li Guangchao G Guo Jintao J Zheng Yanfang Y Ding Wen W Han Zheping Z Qin Lingyu L Mo Wenjun W Luo Min M
Molecular therapy oncolytics 20210716
The efficacy of chimeric antigen receptor (CAR) T is still not optimal for solid tumors, partly due to the lack of T cell infiltration to the tumor site. One promising strategy is to guide T cells through tumor-specific chemokines, provided that the matching chemokine receptors are expressed on T cells. Previous reports showed that, for non-small cell lung cancer (NSCLC) patients, the tumor sites express high levels of chemokine CXCL13, whereas CXCR5, the only receptor for CXCL13, is mainly expr ...[more]