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Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro.

ABSTRACT: Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC₉₀ value are achievable for 24 h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.

SUBMITTER: Murray J

PROVIDER: S-EPMC8433326 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro.

Murray Jackelyn J Hogan Robert J RJ Martin David E DE Blahunka Kathy K Sancilio Fred D FD Balyan Rajiv R Lovern Mark M Still Richard R Tripp Ralph A RA

Scientific reports 20210910 1

Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC<sub>90</sub> value are achievable for ...[more]

PMID: 34508172

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