Mapping inertial migration in the cross section of a microfluidic channel with high-speed imaging.

ABSTRACT: The wide adoption of inertial microfluidics in biomedical research and clinical settings, such as rare cell isolation, has prompted the inquiry of its underlying mechanism. Although tremendous improvement has been made, the mechanism of inertial migration remains to be further elucidated. Contradicting observations are not fully reconciled by the existing theory, and details of the inertial migration within channel cross sections are missing in the literature. In this work, for the first time, we mapped the inertial migration pathways within channel cross section using high-speed imaging at the single-particle level. This is in contrast to the conventional method of particle streak velocimetry (PSV), which provides collective information. We also applied smoothed particle hydrodynamics (SP

SUBMITTER: Zhou J 

PROVIDER: S-EPMC8433405 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature