Temperature dependence of the microwave dielectric properties of [Formula: see text]-aminobutyric acid.

ABSTRACT: The GABA molecule is the major inhibitory neurotransmitter in the mammalian central nervous system. Through binding to post-synaptic neurons, GABA reduces the neuronal excitability by hyperpolarization. Correct binding between the GABA molecules and its receptors relies on molecular recognition. Earlier studies suggest that recognition is determined by the geometries of the molecule and its receptor. We employed dielectric relaxation spectroscopy (DRS) to study the conformation and dielectric properties of the GABA molecule under physiologically relevant laboratory conditions. The dielectric properties of GABA investigated have given us new insights about the GABA molecule, such as how they interact with each other and with water molecules at different temperatures (22°C and 37.5°C). Highe

SUBMITTER: Hou J 

PROVIDER: S-EPMC8433407 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature