A method for large-scale implantation of 3D microdevice ensembles into brain and soft tissue.

ABSTRACT: Wireless networks of implantable electronic sensors and actuators at the microscale (sub-mm) level are being explored for monitoring and modulation of physiological activity for medical diagnostics and therapeutic purposes. Beyond the requirement of integrating multiple electronic or chemical functions within small device volumes, a key challenge is the development of high-throughput methods for the implantation of large numbers of microdevices into soft tissues with minimal damage. To that end, we have developed a method for high-throughput implantation of ~100-200 µm size devices, which are here simulated by proxy microparticle ensembles. While generally applicable to subdermal tissue, our main focus and experimental testbed is the implantation of microparticles into the brain. The metho

SUBMITTER: Sigurdsson SA 

PROVIDER: S-EPMC8433454 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature