Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration.

ABSTRACT: Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders, which represent the leading global cause of disability. Cellular senescence was initially described by Hayflick et al. in 1961 as an irreversible nondividing state in in vitro cell culture studies. We now know that cellular senescence can occur in vivo in response to various stressors as a heterogeneous and tissue-specific cell state with a secretome phenotype acquired after the initial growth arrest. In the past two decades, compelling evidence from preclinical models and human data show an accumulation of senescent cells in many components of the musculoskeletal system. Cellular senescence is therefore a defining feature of age-related musculoskeletal disorders, and targeted eli

SUBMITTER: Wan M 

PROVIDER: S-EPMC8433460 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature