Bioinspired microcone-array-based living biointerfaces: enhancing the anti-inflammatory effect and neuronal network formation.

ABSTRACT: Implantable neural interfaces and systems have attracted much attention due to their broad applications in treating diverse neuropsychiatric disorders. However, obtaining a long-term reliable implant-neural interface is extremely important but remains an urgent challenge due to the resulting acute inflammatory responses. Here, bioinspired microcone-array-based (MA) interfaces have been successfully designed, and their cytocompatibility with neurons and the inflammatory response have been explored. Compared with smooth control samples, MA structures cultured with neuronal cells result in much denser extending neurites, which behave similar to creepers, wrapping tightly around the microcones to form complex and interconnected neuronal networks. After further implantation in mouse brains for

SUBMITTER: Chen H 

PROVIDER: S-EPMC8433467 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature