Infrared neural stimulation and inhibition using an implantable silicon photonic microdevice.

ABSTRACT: Brain is one of the most temperature sensitive organs. Besides the fundamental role of temperature in cellular metabolism, thermal response of neuronal populations is also significant during the evolution of various neurodegenerative diseases. For such critical environmental factor, thorough mapping of cellular response to variations in temperature is desired in the living brain. So far, limited efforts have been made to create complex devices that are able to modulate temperature, and concurrently record multiple features of the stimulated region. In our work, the in vivo application of a multimodal photonic neural probe is demonstrated. Optical, thermal, and electrophysiological functions are monolithically integrated in a single device. The system facilitates spatial and temporal contro

SUBMITTER: Horvath AC 

PROVIDER: S-EPMC8433474 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature