RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates.

ABSTRACT: Plasticity of cells, tissues, and organs is controlled by the coordinated transcription of biological programs. However, the mechanisms orchestrating such context-specific transcriptional networks mediated by the dynamic interplay of transcription factors and coregulators are poorly understood. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a prototypical master regulator of adaptive transcription in various cell types. We now uncovered a central function of the C-terminal domain of PGC-1α to bind RNAs and assemble multiprotein complexes including proteins that control gene transcription and RNA processing. These interactions are important for PGC-1α recruitment to chromatin in transcriptionally active liquid-like nuclear condensates. Notably, such a compartmen

SUBMITTER: Perez-Schindler J 

PROVIDER: S-EPMC8433555 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature