STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [¹⁸F]FLT PET imaging.

ABSTRACT: Type I interferons (IFNs) are critical effectors of emerging cancer immunotherapies designed to activate pattern recognition receptors (PRRs). A challenge in the clinical translation of these agents is the lack of noninvasive pharmacodynamic biomarkers that indicate increased intratumoral IFN signaling following PRR activation. Positron emission tomography (PET) imaging enables the visualization of tissue metabolic activity, but whether IFN signaling-induced alterations in tumor cell metabolism can be detected using PET has not been investigated. We found that IFN signaling augments pancreatic ductal adenocarcinoma (PDAC) cell nucleotide metabolism via transcriptional induction of metabolism-associated genes including thymidine phosphorylase (TYMP). TYMP catalyzes the first step in the cat

SUBMITTER: Liang K 

PROVIDER: S-EPMC8433573 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature