Dataset Information

Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.

ABSTRACT: Group A rotaviruses cause severe gastroenteritis in infants and young children worldwide, with P[II] genogroup rotaviruses (RVs) responsible for >90% of global cases. RVs have diverse host ranges in different human and animal populations determined by host histo-blood group antigen (HBGA) receptor polymorphism, but details governing diversity, host ranges, and species barriers remain elusive. In this study, crystal structures of complexes of the major P[II] genogroup P[4] and P[8] genotype RV VP8* receptor-binding domains together with Lewis epitope-containing LNDFH I glycans in combination with VP8* receptor-glycan ligand affinity measurements based on NMR titration experiments revealed the structural basis for RV genotype-specific switching between ββ and βα HBGA receptor-binding sites that determine RV host ranges. The data support the hypothesis that P[II] RV evolution progressed from animals to humans under the selection of type 1 HBGAs guided by stepwise host synthesis of type 1 ABH and Lewis HBGAs. The results help explain disease burden, species barriers, epidemiology, and limited efficacy of current RV vaccines in developing countries. The structural data has the potential to impact the design of future vaccine strategies against RV gastroenteritis.

SUBMITTER: Xu S

PROVIDER: S-EPMC8433580 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.

Xu Shenyuan S McGinnis Kristen Rose KR Liu Yang Y Huang Pengwei P Tan Ming M Stuckert Michael Robert MR Burnside Riley Erin RE Jacob Elsa Grace EG Ni Shuisong S Jiang Xi X Kennedy Michael A MA

Proceedings of the National Academy of Sciences of the United States of America 20210901 36

Group A rotaviruses cause severe gastroenteritis in infants and young children worldwide, with P[II] genogroup rotaviruses (RVs) responsible for >90% of global cases. RVs have diverse host ranges in different human and animal populations determined by host histo-blood group antigen (HBGA) receptor polymorphism, but details governing diversity, host ranges, and species barriers remain elusive. In this study, crystal structures of complexes of the major P[II] genogroup P[4] and P[8] genotype RV VP ...[more]

PMID: 34475219

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Dataset Information

Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.

Publications

Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens.

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