Dataset Information

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P₁ Agonist and Functional Antagonist Potency In Vitro and In Vivo.

ABSTRACT: Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P₁ internalization upon S1P binding and recycling to the cell surface when local S1P concentrations are low drives T cell trafficking. S1P₁ modulators, such as fingolimod, disrupt this recycling by inducing persistent S1P₁ internalization and receptor degradation, which results in blocked egress of T cells from the secondary lymphoid tissues. The approval of these compounds for the treatment of multiple sclerosis has placed the development of S1PR modulators in the focus of pharmacological research, mostly for autoimmune indications. Here, we repor

SUBMITTER: Stepanovska Tanturovska B

PROVIDER: S-EPMC8433829 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P₁ Agonist and Functional Antagonist Potency In Vitro and In Vivo.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo.

OmicsDI is part of the ELIXIR infrastructure

Tweets

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P₁ Agonist and Functional Antagonist Potency In Vitro and In Vivo.