Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration.

ABSTRACT: Multiple viral targets are now available in the clinic to fight HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic failures in patients due to resistance, with or without treatment-adherence glitches. Accordingly, it is important to better understand how HIV and other retroviruses replicate in order to propose alternative antiviral strategies. Recent studies have shown that multiple cellular factors are implicated during the integration step and, more specifically, that integrase can be regulated through post-translational modifications. We have shown that integrase is phosphorylated by GCN2, a cellular protein kinase of the integrated stress response, leading to a restriction of HIV replication. In a

SUBMITTER: Torres C 

PROVIDER: S-EPMC8434491 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature