Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish.

ABSTRACT: The models of oxidative damage-induced aging were established by adding ethanol (C₂H₅OH), hydrogen peroxide (H₂O₂) and 6-hydroxydopamine (6-OHDA) to zebrafish embryos in this research. To find effective protective drugs/foods, Salvianolic acid B (Sal B) was added after the embryos were treated by these oxidative reagents. After being treated with ethanol, H₂O₂ and 6-OHDA, the morphological changes were obvious and the deformities included spinal curvature, heart bleeding, liver bleeding, yolk sac deformity and pericardial edema, and the expression of oxidative stress-related genes Nrf2b, sod1 and sod2 and aging-related genes myl2a and selenbp1 were significantly up-regulated compared to the

SUBMITTER: Li E 

PROVIDER: S-EPMC8434535 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature