Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction.

ABSTRACT:

Background

Innate lymphoid cells type 2 (ILC2s) play critical homeostatic functions in peripheral tissues. ILC2s reside in perivascular niches and limit atherosclerosis development.

Objectives

ILC2s also reside in the pericardium but their role in postischemic injury is unknown.

Methods

We examined the role of ILC2 in a mouse model of myocardial infarction (MI), and compared mice with or without genetic deletion of ILC2. We determined infarct size using histology and heart function using echocardiography. We assessed cardiac ILC2 using flow cytometry and RNA sequencing. Based on these data, we devised a therapeutic strategy to activate ILC2 in mice with acute MI, using exogenous interleukin (IL)-2. We also assessed the ability of low-dose IL-2 to activate ILC2 in a do

SUBMITTER: Yu X 

PROVIDER: S-EPMC8434674 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature