Prenatal risk factors and neonatal DNA methylation in very preterm infants.

ABSTRACT:

Background

Prenatal risk factors are related to poor health and developmental outcomes for infants, potentially via epigenetic mechanisms. We tested associations between person-centered prenatal risk profiles, cumulative prenatal risk models, and epigenome-wide DNA methylation (DNAm) in very preterm neonates.

Methods

We studied 542 infants from a multi-center study of infants born < 30 weeks postmenstrual age. We assessed 24 prenatal risk factors via maternal report and medical record review. Latent class analysis was used to define prenatal risk profiles. DNAm was quantified from neonatal buccal cells using the Illumina MethylationEPIC Beadarray.

Results

We identified three latent profiles of women: a group with few risk factors (61%) and groups with elevated physica

SUBMITTER: Camerota M 

PROVIDER: S-EPMC8434712 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature