Dataset Information

Using hierarchical similarity to examine the genetics of Behcet's disease.

ABSTRACT:

Objective

Behçet's disease (BD) is a multisystem inflammatory disease that affects patients along the historic silk road. Thus far, the pathogenesis of the disease has proved elusive due to the complex genetic interactions of the disease. In this paper, we seek to clarify the genetic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD.

Results

To do this, we employ a convergent functional genomics approach by leveraging the hierarchical similarity tool available in Geneweaver. Through our analysis, we were able to ascertain 7 BD consensus genes and 16 autoimmune diseases with genetic overlap with BD. The results of our study will inform further research into the pathogenesis of Behçet's disease.

SUBMITTER: Shenoi SJ

PROVIDER: S-EPMC8434716 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Publications

Using hierarchical similarity to examine the genetics of Behçet's disease.

Shenoi Samuel J SJ Baker Erich J EJ

BMC research notes 20210910 1

<h4>Objective</h4>Behçet's disease (BD) is a multisystem inflammatory disease that affects patients along the historic silk road. Thus far, the pathogenesis of the disease has proved elusive due to the complex genetic interactions of the disease. In this paper, we seek to clarify the genetic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD.<h4>Results</h4>To do this, we employ a convergent functional genomics approach by leveragin ...[more]

PMID: 34507623

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