SaccuFlow: A High-Throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions.

ABSTRACT: Bacterial cell walls are formidable barriers that protect bacterial cells against external insults and oppose internal turgor pressure. While cell wall composition is variable across species, peptidoglycan is the principal component of all cell walls. Peptidoglycan is a mesh-like scaffold composed of cross-linked strands that can be heavily decorated with anchored proteins. The biosynthesis and remodeling of peptidoglycan must be tightly regulated by cells because disruption to this biomacromolecule is lethal. This essentiality is exploited by the human innate immune system in resisting colonization and by a number of clinically relevant antibiotics that target peptidoglycan biosynthesis. Evaluation of molecules or proteins that interact with peptidoglycan can be a complicated and, typical

SUBMITTER: Apostolos AJ 

PROVIDER: S-EPMC8434819 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature