Expansion of Unique Hepatitis C Virus-Specific Public CD8⁺ T Cell Clonotypes during Acute Infection and Reinfection.

ABSTRACT: Hepatitis C virus (HCV) infection resolves spontaneously in ∼25% of acutely infected humans where viral clearance is mediated primarily by virus-specific CD8⁺ T cells. Previous cross-sectional analysis of the CD8⁺ TCR repertoire targeting two immunodominant HCV epitopes reported widespread use of public TCRs shared by different subjects, irrespective of infection outcome. However, little is known about the evolution of the public TCR repertoire during acute HCV and whether cross-reactivity to other Ags can influence infectious outcome. In this article, we analyzed the CD8⁺ TCR repertoire specific to the immunodominant and cross-reactive HLA-A2-restricted nonstructural 3-1073 epitope during acute HCV in humans progressing to either spontaneous resolution or

SUBMITTER: Mazouz S 

PROVIDER: S-EPMC8434894 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature