Leptin receptor signaling is required for intact hypoglycemic counterregulation: A study in male Zucker rats.

ABSTRACT: Hypoglycemia is a major barrier to clinical management of persons with diabetes. Emerging evidence supports a role for leptin in gating hypoglycemic counterregulation. This work demonstrates that male leptin receptor null, Zucker (fa/fa), rats display severe impairments in hypoglycemic counterregulation. Thus, augmenting leptin levels may have clinical utility for preventing hypoglycemia.

SUBMITTER: Morrison CD 

PROVIDER: S-EPMC8435018 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature