Vitamin D Receptor Gene Polymorphisms and Risk of Atopic Dermatitis in Chinese Han Population.

ABSTRACT:

Background

Studies investigated the associations between four Vitamin D receptor (VDR) common variations and interactions of gene-environment factors and atopic dermatitis (AD) in Chinese population are few.

Methods

In this case-control study, 400 AD patients and 400 controls were genotyped for the FokI, TaqI, BsmI and ApalI variations of VDR genes by restriction fragment length polymorphism analysis. The associations between VDR genes and AD were assessed by univariate and multivariate logistic regression. The interactions between VDR genes and some risk factors were also explored using cross-over analysis. The corresponding odds ratio (ORs) and 95% confidence intervals (CI) were also calculated.

Results

The FoKI rs2228570 polymorphism was significantly associated wi

SUBMITTER: Ou Y 

PROVIDER: S-EPMC8435479 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature