Microglia and Perivascular Macrophages Act as Antigen Presenting Cells to Promote CD8 T Cell Infiltration of the Brain.

ABSTRACT: CD8 T cell infiltration of the central nervous system (CNS) is necessary for host protection but contributes to neuropathology. Antigen presenting cells (APCs) situated at CNS borders are thought to mediate T cell entry into the parenchyma during neuroinflammation. The identity of the CNS-resident APC that presents antigen via major histocompatibility complex (MHC) class I to CD8 T cells is unknown. Herein, we characterize MHC class I expression in the naïve and virally infected brain and identify microglia and macrophages (CNS-myeloid cells) as APCs that upregulate H-2K^b and H-2D^b upon infection. Conditional ablation of H-2K^b and H-2D^b from CNS-myeloid cells allowed us to determine that antigen presentation via H-2D^b, bu

SUBMITTER: Goddery EN 

PROVIDER: S-EPMC8435747 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature