Specific Gut Microbiome and Serum Metabolome Changes in Lung Cancer Patients.

ABSTRACT:

Background

Lung cancer (LC) is one of the most aggressive, prevalent and fatal malignancies. Gut microbes and their associated metabolites are thought to cause and modulate LC development, albeit influenced by the host genetic make-up and environment. Herein, we identified and classified gut microbiota and serum metabolites associated with LC.

Methods

Stool samples were collected from 41 LC patients and 40 healthy volunteers. The gut microbiota was analyzed using 16S rRNA gene sequencing. Serum samples were collected from the same LC patients (n=30) and healthy volunteers (n=30) and serum metabolites were analyzed using liquid chromatography-mass spectrometry (LC-MS). Microbiome and metabolome data were analyzed separately and integrated for combined analysis using various b

SUBMITTER: Zhao F 

PROVIDER: S-EPMC8435782 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature