Lung function trajectory and biomarkers in the Tasmanian Longitudinal Health Study.

ABSTRACT:

Background and objective

Different lung function trajectories through life can lead to COPD in adulthood. This study investigated whether circulating levels of biomarkers can differentiate those with accelerated (AD) from normal decline (ND) trajectories.

Methods

The Tasmanian Longitudinal Health Study (TAHS) is a general population study that measured spirometry and followed up participants from ages 7 to 53 years. Based on their forced expiratory volume in 1 s (FEV₁) trajectories from age 7 to 53 years, this analysis included those with COPD at age 53 years (60 with AD and 94 with ND) and controls (n=720) defined as never-smokers with an average FEV₁ trajectory. Circulating levels of selected biomarkers determined at 53 and 45 years of age were compar

SUBMITTER: Bui DS 

PROVIDER: S-EPMC8435806 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature