Bioengineering bacterial encapsulin nanocompartments as targeted drug delivery system.

ABSTRACT: The development of Drug Delivery Systems (DDS) has led to increasingly efficient therapies for the treatment and detection of various diseases. DDS use a range of nanoscale delivery platforms produced from polymeric of inorganic materials, such as micelles, and metal and polymeric nanoparticles, but their variant chemical composition make alterations to their size, shape, or structures inherently complex. Genetically encoded protein nanocages are highly promising DDS candidates because of their modular composition, ease of recombinant production in a range of hosts, control over assembly and loading of cargo molecules and biodegradability. One example of naturally occurring nanocompartments are encapsulins, recently discovered bacterial organelles that have been shown to be reprogrammable

SUBMITTER: Van de Steen A 

PROVIDER: S-EPMC8435816 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature