Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study.

ABSTRACT: Introduction: Corticobasal syndrome (CBS) is a progressive neurological disorder related to multiple underlying pathologies, including four-repeat tauopathies, such as corticobasal degeneration and progressive supranuclear palsy, and Alzheimer's disease (AD). Speech and language are commonly impaired, encompassing a broad spectrum of deficits. We aimed to investigate CBS speech and language impairment patterns in light of a multimodal imaging approach. Materials and Methods: Thirty-one patients with probable CBS were prospectively evaluated concerning their speech-language, cognitive, and motor profiles. They underwent positron emission tomography with [¹⁸F]fluorodeoxyglucose (FDG-PET) and [¹¹C]Pittsburgh Compound-B (PIB-PET) on a hybrid PET-MRI machine

SUBMITTER: Parmera JB 

PROVIDER: S-EPMC8435851 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature