Spatiotemporal Patterns of Loco-Regional Recurrence After Breast-Conserving Surgery.

ABSTRACT:

Background

Loco-regional recurrences (LRR) following breast-conserving surgery (BCS) remain a heterogeneous class of disease that has significant variation in its biological behavior and prognosis.

Methods

To delineate the spatiotemporal patterns of LRR after BCS, we analyzed the data of 4325 patients treated with BCS from 2006 to 2016. Clinico-pathological and treatment specific factors were analyzed using the Cox proportional hazards model to identify factors predictive for LRR events. Recurrence patterns were scrutinized based on recurrence type and recurrence-free interval (RFI). Annual recurrence rates (ARR) were compared according to recurrence type and molecular subtype.

Results

With a median follow-up of 66 months, 120 (2.8%) LRRs were recorded as the first si

SUBMITTER: Qu FL 

PROVIDER: S-EPMC8435899 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature