Structural Insights into the Mechanisms and Pharmacology of K_2P Potassium Channels.

ABSTRACT: Leak currents, defined as voltage and time independent flows of ions across cell membranes, are central to cellular electrical excitability control. The K_2P (KCNK) potassium channel class comprises an ion channel family that produces potassium leak currents that oppose excitation and stabilize the resting membrane potential in cells in the brain, cardiovascular system, immune system, and sensory organs. Due to their widespread tissue distribution, K_2Ps contribute to many physiological and pathophysiological processes including anesthesia, pain, arrythmias, ischemia, hypertension, migraine, intraocular pressure regulation, and lung injury responses. Structural studies of six homomeric K_2Ps have established the basic architecture of this channel family, revea

SUBMITTER: Natale AM 

PROVIDER: S-EPMC8436263 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature