Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection.

ABSTRACT:

Background

Biomarkers have been widely explored for coronavirus disease 2019 diagnosis. Both viral RNA or antigens (Ag) in the respiratory system and antibodies (Ab) in blood are used to identify active infection, transmission risk, and immune response but have limitations. This study investigated the diagnostic utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-Ag) in serum.

Methods

We retrospectively studied 208 randomly selected cases with SARS-CoV-2 infection confirmed by viral RNA test in swabs. N-Ag concentrations were measured in remnant serum samples, compared to viral RNA or Ab results, and correlated to electronic health records for clinical value evaluation.

Results

Serum N-Ag was detected during active infection

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8436384 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature