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ABSTRACT:
SUBMITTER: Popadynec M
PROVIDER: S-EPMC8436412 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Popadynec Michael M Baradaran-Heravi Alireza A Alford Benjamin B Cameron Scott A SA Clinch Keith K Mason Jennifer M JM Rendle Phillip M PM Zubkova Olga V OV Gan Zhonghong Z Liu Hui H Rebollo Oscar O Whitfield Dennis M DM Yan Fengyang F Roberge Michel M Powell David A DA
ACS medicinal chemistry letters 20210809 9
A significant proportion of genetic disease cases arise from truncation of proteins caused by premature termination codons. In eukaryotic cells some aminoglycosides cause readthrough of premature termination codons during protein translation. Inducing readthrough of these codons can potentially be of therapeutic value in the treatment of numerous genetic diseases. A significant drawback to the repeated use of aminoglycosides as treatments is the lack of balance between their readthrough efficacy ...[more]