Altered functional connectivity is related to impaired cognition in left unilateral asymptomatic carotid artery stenosis patients.

ABSTRACT:

Background

Asymptomatic carotid artery stenosis (aCAS) impairs haemodynamic and cognitive functions; however, the relationship between these changes and brain network connectivity remains largely unknown. This study aimed to determine the relationship between functional connectivity and neurocognition in patients with aCAS.

Methods

We compared functional status in 14 patients with aCAS and 15 healthy controls using resting state functional magnetic resonance imaging sequences. The subjects underwent a full range of neuropsychological tests and a graphical theoretical analysis of their brain networks.

Results

Compared with controls, patients with aCAS showed significant decline in neuropsychological functions, particularly short-term memory (word-memory, p = .046 and p

SUBMITTER: He S 

PROVIDER: S-EPMC8436468 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature