The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity.

ABSTRACT: Cell polarity is essential for spatially regulating of physiological processes in metazoans by which hormonal stimulation‒secretion coupling is precisely coupled for tissue homeostasis and organ communications. However, the molecular mechanisms underlying epithelial cell polarity establishment remain elusive. Here, we show that septin cytoskeleton interacts with catenin complex to organize a functional domain to separate apical from basal membranes in polarized epithelial cells. Using polarized epithelial cell monolayer as a model system with transepithelial electrical resistance as functional readout, our studies show that septins are essential for epithelial cell polarization. Our proteomic analyses discovered a novel septin‒catenin complex during epithelial cell polarization. The functi

SUBMITTER: Wang X 

PROVIDER: S-EPMC8436676 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature