Detection of covert lesions in focal epilepsy using computational analysis of multimodal magnetic resonance imaging data.

ABSTRACT:

Objective

To compare the location of suspect lesions detected by computational analysis of multimodal magnetic resonance imaging data with areas of seizure onset, early propagation, and interictal epileptiform discharges (IEDs) identified with stereoelectroencephalography (SEEG) in a cohort of patients with medically refractory focal epilepsy and radiologically normal magnetic resonance imaging (MRI) scans.

Methods

We developed a method of lesion detection using computational analysis of multimodal MRI data in a cohort of 62 control subjects, and 42 patients with focal epilepsy and MRI-visible lesions. We then applied it to detect covert lesions in 27 focal epilepsy patients with radiologically normal MRI scans, comparing our findings with the areas of seizure onset, early p

SUBMITTER: Kanber B 

PROVIDER: S-EPMC8436754 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature