Stress-induced aberrations in sensory processing predict worse cognitive outcomes in healthy aging adults.

ABSTRACT: It is well recognized that not all individuals age equivalently, with functional dependence attributable, at least in part, to stress accumulated across the lifespan. Amongst these dependencies are age-related declines in cognitive function, which may be the result of impaired inhibitory processing (e.g., sensory gating). Herein, we examined the unique roles of life and biological stress on somatosensory gating dynamics in 74 adults (22-72 years old). Participants completed a sensory gating paired-pulse electrical stimulation paradigm of the right median nerve during magnetoencephalography (MEG) and data were subjected to advanced oscillatory and time-domain analysis methods. We observed separable mechanisms by which increasing levels of life and biological stress predicted higher oscillat

SUBMITTER: Spooner RK 

PROVIDER: S-EPMC8436901 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature