Immune normalization strategy against suboptimal health status: safe and efficacious therapy using mixed-natural killer cells.

ABSTRACT: "Immune normalization" has emerged as a new paradigm in immunotherapy, which is proposed in cancer patients instead of conventional "immune-enhancement" therapy. Immune normalization may also be implemented in cancer prevention of "sub-healthy" individuals. We established in vitro cultured mixed-natural killer (NKM) cells to achieve immune normalization. The in vitro cytotoxicity of NKM cells was tenfold higher than that of peripheral blood mononuclear cells (PBMCs). The cytotoxicity of NKM cells was negatively correlated with the proportion of T-helper cells (cluster of differentiation: CD3+CD4+ T), and positively correlated with the proportion of NK cells (especially CD56^brightCD16^bright NK cells). Then, we defined "sub-healthy individuals" after measu

SUBMITTER: Li Y 

PROVIDER: S-EPMC8436936 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature